Londonio trained as a painter under Ferdinando Porta and Giovanni Battista Sassi in Milan, but traveled to Rome and Naples. He studied engraving with Benigno Bossi. He is best known for his paintings and etchings of rustic and pastoral landscapes and subjects, with both animals and peasants playing a dominating role over the landscape. This focus on genre themes was popular among the wealthy patrons of the time, specially in Northern Italy. He mostly preferred small-format works, describing shepherds and peasants with rapid strokes of the brush and with a vigorous and chromatically lively pictorial paste. His talent allowed him to be one of the most appreciated painters of reality active in Lombardy, between Arcadia and the Enlightenment.
Londonio is also known for his scenography. An example, of this poorly conserved art form that still exists is a nativity scene on cut wooden shapes for the church of San Marco in Milan. The effect is a cheaper version of the naturalistic Sacri Monti scenes, which had been painted stucco statuary. It also can be seen as a cross between the holy scenes described above, and the theatrical set pieces, for example, those needed for the newly founded La Scala theater. The work at San Marco prompted Empress Maria Theresa of Austria appointed Londonio as art designer for La Scala.